The role of necroptosis in neurosurgical diseases
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;48(4): 292-298, 4/2015.
Article
ي En
| LILACS
| ID: lil-744365
المكتبة المسؤولة:
BR1.1
ABSTRACT
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Brain Injuries
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Cerebrovascular Disorders
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Apoptosis
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Receptors, Death Domain
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Necrosis
المحددات:
Humans
اللغة:
En
مجلة:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
موضوع المجلة:
BIOLOGIA
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MEDICINA
السنة:
2015
نوع:
Article
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Project document