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Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula / Causas imputáveis da doença renal crônica em adultos: um estudo retrospectivo de cinco anos de um Hospital de Assistência Terciária no nordeste do Península da Malásia
Salman, Muhammad; Khan, Amer Hayat; Adnan, Azreen Syazril; Sulaiman, Syed Azhar Syed; Hussain, Khalid; Shehzadi, Naureen; Jummaat, Fauziah.
Affiliation
  • Salman, Muhammad; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
  • Khan, Amer Hayat; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
  • Adnan, Azreen Syazril; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
  • Sulaiman, Syed Azhar Syed; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
  • Hussain, Khalid; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
  • Shehzadi, Naureen; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
  • Jummaat, Fauziah; University of the Punjab. University College of Pharmacy. Department of Pharmacy Practice. Lahore-54000. PK
São Paulo med. j ; São Paulo med. j;133(6): 502-509, Nov.-Dec. 2015. tab, graf
Article ي En | LILACS | ID: lil-770155
المكتبة المسؤولة: BR1.1
ABSTRACT
ABSTRACT CONTEXT AND

OBJECTIVE:

Chronic kidney disease (CKD) is an escalating medical and socioeconomic problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable causes of CKD in an adult population at a tertiary referral hospital. DESIGN AND

SETTING:

Retrospective study at Hospital Universiti Sains Malaysia (HUSM).

METHODS:

This was an analysis based on medical records of adult patients at HUSM. Data regarding demographics, laboratory investigations, attributable causes and CKD stage were gathered.

RESULTS:

A total of 851 eligible cases were included. The patients' mean age was 61.18 ± 13.37 years. CKD stage V was found in 333 cases (39.1%) whereas stages IV, IIIb, IIIa, and II were seen in 240 (28.2%), 186 (21.9%), 74 (8.7%) and 18 (2.1%), respectively. The percentage of CKD stage V patients receiving renal replacement therapy was 15.6%. The foremost attributable causes of CKD were diabetic nephropathy (DN) (44.9%), hypertension (HPT) (24.2%) and obstructive uropathy (9.2%). The difference in the prevalence of CKD due to DN, HPT and glomerulonephritis between patients ≤ 50 and > 50 years old was statistically significant.

CONCLUSION:

Our results suggest that DN and HPT are the major attributable causes of CKD among patients at a Malaysian tertiary-care hospital. Furthermore, the results draw attention to the possibility that greater emphasis on primary prevention of diabetes and hypertension will have a great impact on reduction of hospital admissions due to CKD in Malaysia.
RESUMO
RESUMO CONTEXTO E

OBJETIVO:

Doença renal crônica (DRC) é um problema médico e socioeconômico crescente. As informações relativas às causas da DRC são pré-requisito para reduzir a carga da doença, e são escassas na Malásia. Este estudo tem como objetivo avaliar as causas atribuíveis à DRC na população adulta de um hospital de referência terciária. TIPO DE ESTUDO E LOCAL Estudo retrospectivo realizado no Hospital Universiti Sains Malaysia (HUSM).

MÉTODOS:

Análise de prontuários de pacientes adultos de HUSM. Foram obtidos dados demográficos, exames laboratoriais, causas atribuíveis e estágio da DRC.

RESULTADOS:

Um total de 851 casos elegíveis foi incluído. A idade média dos pacientes foi de 61,18 ± 13,37 anos. DRC fase V foi contabilizada em 333 casos (39,1%), enquanto casos de estágio IV, IIIb, IIIa e II foram 240 (28,2%), 186 (21,9%), 74 (8,7%) e 18 (2,1%), respectivamente. A porcentagem de pacientes com DRC estágio V recebendo a terapia de substituição renal foi 15,6%. As causas atribuíveis mais importantes da DRC foram nefropatia diabética (ND) (44,9%), hipertensão (24,2%) e uropatia obstrutiva (9,2%). A diferença na prevalência da DRC devido à ND, hipertensão e glomerulonefrite entre pacientes ≤ 50 anos e > 50 anos de idade foi estatisticamente significativa.

CONCLUSÃO:

Nossos resultados sugerem que a ND e a hipertensão são as principais causas atribuíveis da DRC em pacientes sob cuidados terciários na Malásia. Os resultados apontam para a possibilidade de maior ênfase na prevenção primária da diabetes e hipertensão como impactante na redução das internações hospitalares devidas a DRC na Malásia.
الموضوعات
Key words

النص الكامل: 1 الفهرس: LILACS الموضوع الرئيسي: Renal Insufficiency, Chronic نوع الدراسة: Etiology_studies / Observational_studies / Risk_factors_studies المحددات: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male البلد/الأقليم حسب الموضوع: Asia اللغة: En مجلة: São Paulo med. j موضوع المجلة: Cirurgia Geral / Ciˆncia / Ginecologia / MEDICINA / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica السنة: 2015 نوع: Article

النص الكامل: 1 الفهرس: LILACS الموضوع الرئيسي: Renal Insufficiency, Chronic نوع الدراسة: Etiology_studies / Observational_studies / Risk_factors_studies المحددات: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male البلد/الأقليم حسب الموضوع: Asia اللغة: En مجلة: São Paulo med. j موضوع المجلة: Cirurgia Geral / Ciˆncia / Ginecologia / MEDICINA / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica السنة: 2015 نوع: Article