Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 38(1): 30-38, Jan.-Mar. 2016. tab, graf
Article
ي En
| LILACS
| ID: lil-776499
المكتبة المسؤولة:
BR1.1
ABSTRACT
Objective:
To perform a cost-utility analysis on the treatment of attention deficit hyperactivity disorder (ADHD) with methylphenidate immediate-release (MPH-IR) in children and adolescents from Brazil.Method:
A Markov model was constructed to compare MPH-IR vs. no treatment. A 24-week naturalistic study was conducted to collect transition probabilities and utility data. Effectiveness was expressed as quality-adjusted life-years (QALY), and costs reported in 2014 international dollars (I$). The perspective was the Brazilian Unified Health System as payer, and the time horizon was 6 years.Results:
Of 171 patients, 73 provided information at baseline, and 56 at week 24. Considering the MPH-IR monthly cost of I$ 38, the incremental cost-effectiveness ratio (ICER) of treatment was I$ 9,103/QALY for children and I$ 11,883/QALY for adolescents. In two-way sensitivity analysis, considering one Gross National Product per capita (I$ 11,530) as willingness-to-pay, a cost of no-treatment lower than I$ 45/month would render MPH-IR a cost-saving strategy.Discussion:
MPH-IR treatment of children and adolescents is cost-effective for ADHD patients from the Brazilian public health system perspective. Both patients and the healthcare system might benefit from such a strategy. Trial registration number NCT01705613.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Attention Deficit Disorder with Hyperactivity
/
Cost-Benefit Analysis
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Central Nervous System Stimulants
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Methylphenidate
نوع الدراسة:
Diagnostic_studies
/
Health_economic_evaluation
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Observational_studies
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Prognostic_studies
المحددات:
Adolescent
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Child
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Female
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Humans
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Male
البلد/الأقليم حسب الموضوع:
America do sul
/
Brasil
اللغة:
En
مجلة:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
موضوع المجلة:
PSIQUIATRIA
السنة:
2016
نوع:
Article