A family-based association study of the HTR1B gene in eating disorders
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 38(3): 239-242, July-Sept. 2016. tab
Article
ي En
| LILACS
| ID: lil-792755
المكتبة المسؤولة:
BR1.1
ABSTRACT
Objective:
To explore the association of three polymorphisms of the serotonin receptor 1Dβ gene (HTR1B) in the etiology of eating disorders and their relationship with clinical characteristics.Methods:
We analyzed the G861C, A-161T, and A1180G polymorphisms of the HTR1B gene through a family-based association test (FBAT) in 245 nuclear families. The sample was stratified into anorexia nervosa (AN) spectrum and bulimia nervosa (BN) spectrum. In addition, we performed a quantitative FBAT analysis of anxiety severity, depression severity, and Yale-Brown-Cornell Eating Disorders Scale (YBC-EDS) in the AN and BN-spectrum groups.Results:
FBAT analysis of the A-161T polymorphism found preferential transmission of allele A-161 in the overall sample. This association was stronger when the sample was stratified by spectrums, showing transmission disequilibrium between the A-161 allele and BN spectrum (z = 2.871, p = 0.004). Quantitative trait analysis showed an association between severity of anxiety symptoms and the C861 allele in AN-spectrum participants (z = 2.871, p = 0.004). We found no associations on analysis of depression severity or preoccupation and ritual scores in AN or BN-spectrum participants.Conclusions:
Our preliminary findings suggest a role of the HTR1B gene in susceptibility to development of BN subtypes. Furthermore, this gene might have an impact on the severity of anxiety in AN-spectrum patients.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Anorexia Nervosa
/
Polymorphism, Single Nucleotide
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Receptor, Serotonin, 5-HT1B
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Bulimia Nervosa
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Genetic Association Studies
نوع الدراسة:
Etiology_studies
/
Prognostic_studies
المحددات:
Adolescent
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Adult
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Female
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Humans
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Male
اللغة:
En
مجلة:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
موضوع المجلة:
PSIQUIATRIA
السنة:
2016
نوع:
Article