Praziquantel inhibits Schistosoma mansoni attachment in vitro
Braz. j. med. biol. res
; 23(10): 1005-8, 1990. ilus
Article
ي En
| LILACS
| ID: lil-91641
المكتبة المسؤولة:
BR26.1
ABSTRACT
Male adult Schistosoma mansoni worms were placed in a glass dish containing Tyrode solution and observed for 15 min after addition of praziquantel (0.01 to 1 pmicron M). Praziquantel promoted a concentrationp- and time-dependent inhibition of sucker-mediated attachment of the worm. Attachment inhibition was correlated with shortening of the parasite. We propose that the rapid and total inhibition of worm attachment observed in vitro with 1 micronM praziquantel indicates that therapeutic concentrations of this drug should promote a rapid hepatic shift, in vivo, which may facilitate host tissue reaction
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الفهرس:
LILACS
الموضوع الرئيسي:
Praziquantel
/
Schistosoma mansoni
/
In Vitro Techniques
المحددات:
Animals
اللغة:
En
مجلة:
Braz. j. med. biol. res
موضوع المجلة:
BIOLOGIA
/
MEDICINA
السنة:
1990
نوع:
Article
/
Congress and conference