Efectos del ácido ursodeoxicólico en pacientes con colestasis gravídica / Effects of ursodeoxycholic acid in patients with cholestasis of pregnancy
Rev. méd. Chile
; 119(2): 169-71, feb. 1991. tab
Article
ي Es
| LILACS
| ID: lil-98201
المكتبة المسؤولة:
CL1.1
ABSTRACT
In an open, pilot study, the efficancy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy was investigated. four patients received 1 g/ñday of UDCA during 20 days and another 2 patients received identical periods of treatment separated by a 14-day interval free of drug. Pruritus and serum levels of toal bile salts and glutamic-pyruvic transaminase improved significantly during treatment with UDCA. Although pruritus and the laboratory alterations had a relapse in the second week after UDCA was discontinued, they improved again in the patients who received a second treatment with UDCA. No adverse reactions were detected in the mothers or in their babies. All neuborns are thriving normally, in a follow-up lasted 3 to 6 months after delivery. It is concluded that UDCA appears to be safe when administered in late pregnancy; its primising efficacy in the treatment of intrahepatic cholestasis of pregnancy should now be confirmed in controlled clinical trials
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الفهرس:
LILACS
الموضوع الرئيسي:
Pregnancy Complications
/
Ursodeoxycholic Acid
/
Cholestasis, Intrahepatic
نوع الدراسة:
Observational_studies
/
Prognostic_studies
المحددات:
Adult
/
Female
/
Humans
/
Pregnancy
اللغة:
Es
مجلة:
Rev. méd. Chile
موضوع المجلة:
MEDICINA
السنة:
1991
نوع:
Article
/
Congress and conference
/
Project document