Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs.
Indian J Physiol Pharmacol
; 1996 Jan; 40(1): 29-34
Article
ي En
| IMSEAR
| ID: sea-107068
ABSTRACT
The effects of anti-epileptic drugs (AEDs) on brainstem auditory evoked potentials (BAEPs) were studied on 32 female patients of epilepsy and 10 age-matched normal healthy females (NS). The patients were divided into 6 groups, those not receiving medication (drug free, DF) and those receiving AEDs Phenytoin (PHT), Carbamazepine (CBZ), Phenobarbital (PB), a combination of PHT and PB and a combination of CBZ and PB. DF epileptics had shortened were V absolute latency (AL) and I-V interpeak latency (IPL) as compared to NS. Phenytoin and CBZ monotherapy produced a prolongation of wave III AL (by PHT only), wave V AL, wave I-III IPL and I-V IPL, as compared to DF epileptics. Phenytoin monotherapy also prolonged wave III AL and I-III IPL, as compared to NS. When PB in the dosage of 30-60 mg/d was used in combination with PHT the above mentioned changes were not observed. These findings indicate altered neuronal conduction and/or synaptic transmission in epileptics. Anti-epileptic drugs in the dosages studied, with exception of PHT appear to lead towards "normalization" of BAEPs.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Phenobarbital
/
Phenytoin
/
Acoustic Stimulation
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Female
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Humans
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Carbamazepine
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Evoked Potentials, Auditory, Brain Stem
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Adolescent
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Adult
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Drug Combinations
نوع الدراسة:
Clinical_trials
اللغة:
En
مجلة:
Indian J Physiol Pharmacol
السنة:
1996
نوع:
Article