Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.
Indian J Physiol Pharmacol
; 2005 Jan; 49(1): 111-4
Article
ي En
| IMSEAR
| ID: sea-107285
ABSTRACT
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Rats
/
Selenium
/
Succinate Dehydrogenase
/
Male
/
Administration, Oral
/
Rats, Wistar
/
Curcumin
/
Enzyme Inhibitors
/
L-Lactate Dehydrogenase
/
Liver
اللغة:
En
مجلة:
Indian J Physiol Pharmacol
السنة:
2005
نوع:
Article