Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs.
Indian J Physiol Pharmacol
; 1987 Apr-Jun; 31(2): 111-6
Article
ي En
| IMSEAR
| ID: sea-107723
ABSTRACT
ST-93, a clonidine analog was studied for its antiarrhythmic activity in anaesthetised guinea pigs against ouabain induced arrhythmia. The amount of ouabain required (micrograms/kg) for the production of ventricular premature best. Ventricular fibrillation and cardiac arrest was recorded in control and drug treated group of animals. Both ST-93 and clonidine produced significant antiarrhythmic effect in guinea pigs. This protective effect was significantly blocked by yohimbine, suggesting that the antiarrhythmic effect is mediated through presynaptic alpha 2-adrenoceptors.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Ouabain
/
Arrhythmias, Cardiac
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Yohimbine
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Female
/
Male
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Clonidine
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Guinea Pigs
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Hemodynamics
/
Animals
/
Anti-Arrhythmia Agents
اللغة:
En
مجلة:
Indian J Physiol Pharmacol
السنة:
1987
نوع:
Article