Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine.
J Postgrad Med
; 2008 Oct-Dec; 54(4): 316-7
Article
ي En
| IMSEAR
| ID: sea-115742
ABSTRACT
Lamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Poisoning
/
Triazines
/
Long QT Syndrome
/
Female
/
Humans
/
Citalopram
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Chlorpheniramine
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Administration, Oral
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Treatment Outcome
/
Sodium Bicarbonate
اللغة:
En
مجلة:
J Postgrad Med
السنة:
2008
نوع:
Article