Cytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases).
Indian J Hum Genet
; 2005 May; 11(2): 94-98
Article
ي En
| IMSEAR
| ID: sea-143337
ABSTRACT
BACKGROUND:
First trimester pregnancy loss is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important cause of recurrent pregnancy loss particularly in the first trimester.AIMS:
In this study an evaluation of the contribution of chromosomal anomalies in causing repeated spontaneous abortions was made. METHODS AND MATERIALS A review of the cytogenetic data in 742 couples (1484 individuals) with recurrent spontaneous abortions who were examined for chromosomal aberrations in the period 1990-2003 is presented. Women who had at least two abortions, or spontaneous abortions preceded or followed by fetal deaths or birth of a malformed child, and patients who had recurrent spontaneous abortions (> 3) with normal live issue/s were studied.RESULTS:
Chromosomal rearrangements were found in 31 individuals (2%). These abnormalities included 22 (2.9%) structural aberrations, 9 (1.2%) numerical anomalies. In addition to these abnormalities, 21 (3.2%) chromosomal variants were also found.CONCLUSION:
Chromosomal analysis is an important etiological investigation in couples with repeated spontaneous abortions as it helps in genetic counseling and deciding about further reproductive options.
النص الكامل:
1
الفهرس:
IMSEAR
نوع الدراسة:
Etiology_studies
اللغة:
En
مجلة:
Indian J Hum Genet
السنة:
2005
نوع:
Article