Immunosuppressant effect of Boswellia serrata extract on CFA induced arthritis in rats
Article
| IMSEAR
| ID: sea-199857
ABSTRACT
Background:
Rheumatoid arthritis (RA) is an immune-mediated arthropathy, so for the treatment disease modifying antirheumatoid drugs are required. In this study we are evaluating the immunomodulatory property of Boswellia serrata extract (BSE) as an alternative medicine.Methods:
Complete Freund’s adjuvant (CFA), 0.1ml was injected intradermally in the footpad of left hind paw in 36 Wistar rats to induce RA. Animals were divided into 6 groups. BSE in the doses of 45mg/kg, 90mg/kg and 180mg/kg was administered and cyclophosphamide as standard drug. Various parameters as body weight, paw thickness, ankle diameter, paw volume, arthritis index, TNF- ? and histopathological changes were analyzed.Results:
Marked reduction in paw thickness, ankle diameter, paw volume, arthritis index and an improved body weight was found in high dose BSE (180mg/kg) group but the effect was lesser than standard drug Cyclophosphamide.Conclusions:
BSE has significant potential as an alternative medicine for treatment of autoimmune diseases like rheumatoid arthritis.
النص الكامل:
1
الفهرس:
IMSEAR
السنة:
2018
نوع:
Article