Phenytoin Induced Gingival Enlargement
Indian J Prev Soc Med
; 2022 Jun; 53(2): 149-154
Article
| IMSEAR
| ID: sea-224006
ABSTRACT
Certain anticonvulsants, cyclosporine, and calcium channel blockers like amlodipine have been shown to produce clinically and histologically similar gingival enlargements in certain susceptible patients in response to local factors. These drugs appear to be similar with respect to their pharmacologic mechanism of action at the cellular level. Therefore, it is tempting to speculate that these agents may act similarly on gingival connective tissue and cause a hyperplastic response. This tissue reaction may involve a disturbance of calcium ion influx into specific cell populations with a resulting alteration in collagen metabolism and other host cell response mechanisms. A connection between ion exchange, folate uptake, collagenase activation, and bacterial inflammation may exist. The management involves Phase I therapy followed by surgical intervention. The purpose of these case reports is to highlight certain modifications in existing surgical techniques like gingivectomy, to have better aesthetic and functional outcome.
النص الكامل:
1
الفهرس:
IMSEAR
مجلة:
Indian J Prev Soc Med
السنة:
2022
نوع:
Article