Synthesis, physico-chemical and biological properties of some alkali metals and quaternary alkylammonium salts of polyene antibiotics: amphotericin B, nystatin and aureofungin.
Hindustan Antibiot Bull
; 1994 Feb-May; 36(1-2): 34-8
Article
ي En
| IMSEAR
| ID: sea-2430
ABSTRACT
Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Polyenes
/
Candida albicans
/
Chemistry, Physical
/
Amphotericin B
/
Nystatin
/
Chemical Phenomena
/
Quaternary Ammonium Compounds
/
Metals
/
Antifungal Agents
اللغة:
En
مجلة:
Hindustan Antibiot Bull
السنة:
1994
نوع:
Article