Effects of prednisolone and dexamethasone on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans.
Indian J Biochem Biophys
; 1989 Aug; 26(4): 278-9
Article
ي En
| IMSEAR
| ID: sea-28502
ABSTRACT
Administration of either prednisolone or dexamethasone (10 mg/kg body wt/day/oral) to rats for 21 days resulted in inhibition of (pro)insulin biosynthesis and immunoreactive insulin release by isolated islets. A gradual reversal of prednisolone's effect was obtained after exposing islets to increasing glucose concentrations but glucose challenges failed to influence dexamethasone's effect.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Proinsulin
/
Rats
/
Male
/
Dexamethasone
/
Prednisolone
/
Islets of Langerhans
/
Insulin
/
Animals
اللغة:
En
مجلة:
Indian J Biochem Biophys
السنة:
1989
نوع:
Article