A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from western Thailand.
Southeast Asian J Trop Med Public Health
; 2004 Jun; 35(2): 281-7
Article
ي En
| IMSEAR
| ID: sea-33968
ABSTRACT
Allelic variation in the Plasmodium falciparum circumsporozoite protein (CS) gene has been determined by sequencing the immunodominant T-cell epitopes, Th2R and Th3R, from 95 isolates from two malaria-endemic areas in the west of Thailand. Comparison with a reference sequence revealed only non-synonymous point mutations in the two epitope regions. Point mutations were found outside these epitopes in a minority of samples, and all but four were also non-synonymous. A relatively high number of variants, 11 Th2R and 9 Th3R, were detected and comprised some that had not been previously observed. However, the Th2R*05 and the Th3R*01 allelic variants predominated, as they were found in more than 70% of the 101 sequences obtained.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Plasmodium falciparum
/
Polymorphism, Genetic
/
Thailand
/
Base Sequence
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Repetitive Sequences, Nucleic Acid
/
Protozoan Proteins
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DNA, Protozoan
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Malaria, Falciparum
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Epitopes, T-Lymphocyte
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Alleles
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Southeast Asian J Trop Med Public Health
السنة:
2004
نوع:
Article