Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina.
Indian J Exp Biol
; 1992 Dec; 30(12): 1176-80
Article
ي En
| IMSEAR
| ID: sea-59211
ABSTRACT
Three agents known to induce release of mast cell constituents, viz. polymyxin, compound 48/80 and polysorbate-80, were evaluated for effect on perfused blood vessels of R. tigrina and B. melanostictus. The mast cell degranulators caused vasoconstriction in frog and toad, except that for P-80 whose responses in toad were equivocal. Toads showed a general low responsiveness in comparison to frogs. Pharmacologic intervention with pheniramine, metergoline, hydergine, atropine and mecamylamine, respectively ruled out role of histamine, 5-HT, catecholamine or acetylcholine or even autonomic mechanisms in the above phenomena. The observations are suggestive of phylogenetic differences in biochemical profile of mast cells in amphibian species.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Perfusion
/
Polysorbates
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Ranidae
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Tachyphylaxis
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Vasoconstriction
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Bufonidae
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Histamine
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Serotonin
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Polymyxins
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P-Methoxy-N-methylphenethylamine
اللغة:
En
مجلة:
Indian J Exp Biol
السنة:
1992
نوع:
Article