Growth pattern and final height in 21-hydroxylase deficiency.
Indian Pediatr
; 2007 Oct; 44(10): 771-3
Article
ي En
| IMSEAR
| ID: sea-9974
ABSTRACT
Growth pattern and final height were evaluated in 47 children with 21-hydroxylase deficiency to identify factors influencing growth. The subjects were followed-up from the age of 0.6 +/- 1.2 years for 8.8 +/- 3.9 years. Final height SDS was significantly below target height SDS (- 2.5 +/- 1.4 versus - 1.0 +/- 1.0, P < 0.001). Laboratory monitoring and type of disease (salt-wasting or simple virilizing) significantly influenced age-specific height SDS. Age at treatment, frequency of laboratory monitoring and dose of glucocorticoid during infancy influenced final height on univariate analysis; the effect was not sustained on multivariate analysis. Our study emphasizes the need for regular laboratory monitoring and lower glucocorticoid dose during infancy in 21-hydroxylase deficiency.
النص الكامل:
1
الفهرس:
IMSEAR
الموضوع الرئيسي:
Body Height
/
Female
/
Humans
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Male
/
Child
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Child Development
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Retrospective Studies
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Follow-Up Studies
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Adolescent
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Adrenal Hyperplasia, Congenital
نوع الدراسة:
Observational_studies
/
Prognostic_studies
اللغة:
En
مجلة:
Indian Pediatr
السنة:
2007
نوع:
Article