Two new phenylpropanoids from wine-processed Corni Fructus / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 5809-5816, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-1008778
المكتبة المسؤولة:
WPRO
ABSTRACT
Six compounds were isolated from aqueous extract of wine-processed Corni Fructus through silica gel, ODS column chromatography, Sephadex LH-20 gel column chromatography, reverse phase preparative HPLC and other chromatographic separation technologies. Their structures were identified with multiple spectroscopical methods including HR-ESI-MS, UV, IR, NMR and ECD and so on. Their structures were established as pinoresinoside B(1), cornusgallicacid A(2),(+)-isolariciresinol-9'-O-β-glucopyranoside(3),(-)-isolariciresinol 3α-O-β-D-glucopyranoside(4),(7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside(5), and(-)-seco isolariciresinol-9'-O-β-D-glucopyranoside(6). Among them, compounds 1 and 2 were two new compounds. The biological activity evaluation results showed that compounds 2 and 6 had strong DPPH free radical scavenging ability, with EC_(50) values of(4.18±1.96) and(21.45±1.19) μmol·L~(-1), respectively. Compounds 1 and 2 had protective effects on H_2O_2-induced oxidative damage in NRK-52E cells in a dose-dependent manner, and the cell survival rate of compound 2 at 100 μmol·L~(-1) was 96.09%±1.77%.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Wine
/
Cornus
/
Lignin
/
Naphthols
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2023
نوع:
Article