Research progress of the effect of "gut-immune" axis on bone homeostasis / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
; (12): 1146-1150, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-1009467
المكتبة المسؤولة:
WPRO
ABSTRACT
Bone homeostasis is based on the dynamic balance of bone formation and bone resorption. An imbalance in bone homeostasis is a major contributor to many skeletal diseases, including osteoporosis. Changes in the composition and diversity of the gut microbiota (GM) are supposed to have a significant impact on bone homeostasis and are closely correlated with changes in bone mass and bone microarchitecture. The "gut-immune" axis, which is formed by the interaction between the host intestinal immune system and GM, is essential for maintaining bone homeostasis, as well as regulating the body's immunological response and maintaining immune homeostasis throughout the intestine and body. The article reviews recent advances in the study of GM, the immune system, and their synergistic impact on bone homeostasis.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Bone Density
/
Gastrointestinal Tract
/
Gastrointestinal Microbiome
/
Homeostasis
/
Immune System
اللغة:
Zh
مجلة:
Chinese Journal of Cellular and Molecular Immunology
السنة:
2023
نوع:
Article