The current status of hormone treatment for prostate cancer patients in Korean real-world practice: a multi-institutional observational study / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 115-120, 2019.
Article
ي En
| WPRIM
| ID: wpr-1009684
المكتبة المسؤولة:
WPRO
ABSTRACT
We aimed to evaluate the current nationwide trend, efficacy, safety, and quality of life (QoL) profiles of hormone treatment in real-world practice settings for prostate cancer (PCa) patients in Korea. A total of 292 men with any biopsy-proven PCa (TanyNanyMany) from 12 institutions in Korea were included in this multi-institutional, observational study of prospectively collected data. All luteinizing hormone-releasing hormone (LHRH) agonists were allowed to be investigational drugs. Efficacy was defined as (1) the rate of castration (serum testosterone ≤50 ng dl-1) at 4-week visit and (2) breakthrough (serum testosterone >50 ng dl-1 after castration). Safety assessments included routine examinations for potential adverse events, laboratory tests, blood pressure, body weight, and bone mineral density (BMD, at baseline and at the last follow-up visit). QoL was assessed using the Expanded Prostate Cancer Index Composite-26 (EPIC-26). The most common initial therapeutic regimen was LHRH agonist with anti-androgen (78.0%), and the most commonly used LHRH agonist for combination and monotherapy was leuprolide (64.0% for combination and 58.0% for monotherapy). The castration and breakthrough rates were 78.4% and 6.6%, respectively. The laboratory results related to dyslipidemia worsened after 4 weeks of hormone treatment. In addition, the mean BMD T-score was significantly lower at the last follow-up (mean -1.950) compared to baseline (mean -0.195). The mean total EPIC-26 score decreased from 84.8 (standard deviation [s.d.] 12.2) to 78.3 (s.d. 8.1), with significant deterioration only in the urinary domain (mean 23.5 at baseline and 21.9 at the 4-week visit). These findings demonstrate the nationwide trend of current practice settings in hormone treatment for PCa in Korea.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prostatic Neoplasms
/
Quality of Life
/
Testosterone
/
Triglycerides
/
Cholesterol
/
Treatment Outcome
/
Leuprolide
/
Receptors, LHRH
/
Antineoplastic Agents, Hormonal
/
Drug Therapy, Combination
المحددات:
Aged
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Asian Journal of Andrology
السنة:
2019
نوع:
Article