Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1287-1292, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-1009883
المكتبة المسؤولة:
WPRO
ABSTRACT
Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schönlein purpura, has complex etiology and pathogenesis which have not been fully clarified. The latest research shows that SARS-CoV-2 and related vaccines, human papilloma vaccine, and certain biological agents can also induce IgAV. Most studies believe that the formation of galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complex plays a crucial role in the pathogenesis of IgAV. It is hypothesized that the pathogenesis of IgAV is associated with the binding of IgA1 to anti-endothelial cell antibodies. In addition, genetics also constitutes a major focus of IgAV research. This article reviews the new advances in the etiology of IgAV and summarizes the role of Gd-IgA1, Gd-IgA1-containing immune complex, anti-endothelial antibody, IgA1 conjugates, T lymphocyte immunity, and genetic factors in the pathogenesis of IgAV.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
IgA Vasculitis
/
Immunoglobulin A
/
Antigen-Antibody Complex
المحددات:
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Contemporary Pediatrics
السنة:
2023
نوع:
Article