Clinical analysis of autologous hematopoietic stem cell transplantation in the treatment of advanced/recurrent nasal type extranodal NK/T-cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 569-572, 2018.
Article
ي Zh
| WPRIM
| ID: wpr-1011812
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To analyze the efficacy and safety of asparaginase based chemotherapy bridging autologous hematopoietic stem cell transplantation (auto-HSCT) in the treatment of 16 patients with nasal type extranodal NK/T-cell lymphoma (ENKTL).Methods:
From January 2012 to June 2017, 16 patients with nasal type extranodal NK/T-cell lymphoma reached complete remission by L-asparaginase based regimens, and then received auto-HSCT.Results:
①Of the 16 patients, 12 were males and 4 females, with a median age of 35.5 (14-61) years. There were 11 patients in the first complete remission (CR1) and 5 in the second CR (CR2) before transplantation, respectively. EB virus (EBV) DNA (EBV-DNA) was negative and positive in 13 and 3 cases respectively before transplantation. ②Hematopoietic reconstitution was achieved in all 16 cases. The median time for neutrophils implantation was 12 (8-17) days, and that of platelet implantation was 15.5 (12-24) days. ③To the last follow-up, there were no transplant related deaths, 3 patients died of disease progression. The median overall survival (OS) time and progression-free survival time (PFS) were not reached. Seven patients lived with no disease progression more than 2 years. ④The OS and PFS of patients at CR(1) before auto-HSCT are better than that of patients at CR(2), but there was no statistically significant difference (P=0.162, P=0.123). There was no significant difference in OS and PFS between EBV-DNA negative and positive patients before transplantation (P=0.280, P=0.244).Conclusions:
L-asparaginase based regimens bridging auto-HSCT is a safe and highly effective for advanced-stage and relapsed ENKTL treatment.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Asparaginase
/
Transplantation, Autologous
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Antineoplastic Combined Chemotherapy Protocols
/
Nose Neoplasms
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Hematopoietic Stem Cell Transplantation
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Lymphoma, Extranodal NK-T-Cell
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Neoplasm Recurrence, Local
المحددات:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2018
نوع:
Article