Clinical analyses of 24 patients with primary pulmonary NK/T-cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 40-46, 2020.
Article
ي Zh
| WPRIM
| ID: wpr-1012137
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To explore the clinical characteristics, the best treatment and prognostic factors of primary pulmonary NK/T-cell lymphoma.Methods:
A total of 24 cases with primary pulmonary NK/T-cell lymphoma from April 2011 to May 2019 were analyzed retrospectively. Survival analysis was performed using the Kaplan-Meier method and groups were compared using the log-rank test. Multivariate analysis using Cox proportional hazard regression model was conducted to confirm independent prognostic factors for overall survival (OS) and progression-free survival (PFS) .Results:
①The cohort of 24 patients included 16 male and 8 female with a median age of 49 years (range, 4-76 years) old. ②Most patients initially presented with a fever (66.7%) , cough and dyspnea. Chest imaging manifestations were primarily unilateral (45.8%) or bilateral (54.2%) pulmonary consolidation, nodules or mass. ③20 patients received chemotherapy, radiotherapy or hematopoietic stem cell transplantation, the rest 4 cases palliative treatment. Median OS was 9.5 months (range, 0.1-26.0 months) . The estimated 1-year OS rate was 45.8%. Overall response rate of patients treated with asparaginase-based regimen was 88.2%. ④In univariate survival analysis, age≤60 was prognostic for longer OS and PFS, compared with age>60 (P=0.002 and 0.004, respectively) ; ECOG≤2 was prognostic for longer OS and PFS, compared with ECOG>2 (P=0.042 and 0.004, respectively) . In multivariate survival analysis, age>60 and ECOG>2 were significantly correlated with inferior OS and PFS (OS P=0.024 and 0.024, respectively; PFS P=0.035 and 0.024, respectively) .Conclusions:
Primary pulmonary NK/T-cell lymphoma was a rare disease with poor prognosis. Asparaginase-based regimens appeared to be effective. Age and ECOG served as independent prognostic factors for primary pulmonary NK/T-cell lymphoma patients.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prognosis
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Asparaginase
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Antineoplastic Combined Chemotherapy Protocols
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Retrospective Studies
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Disease-Free Survival
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Lymphoma, Extranodal NK-T-Cell
المحددات:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2020
نوع:
Article