Activator protein-1 complex and ischemic stroke / 国际脑血管病杂志

ABSTRACT

The activator protein-1 (AP-1) complex is a transcription factor complex composed of Jun, Fos, activating transcription factors, and MAF protein subunits, involved in physiological and pathological processes such as cell proliferation, differentiation, apoptosis, and stress response. In recent years, research has shown that the AP-1 complex plays an important role in ischemic stroke, participating in processes such as microglial activation and neuronal apoptosis after ischemic brain injury, affecting the progression of neuroinflammation and the degree of neurological dysfunction after stroke.