Polymorphisms in the SERPINA1 Gene and the Risk of Chronic Obstructive Pulmonary Disease in a Korean Population / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 285-291, 2008.
Article
ي En
| WPRIM
| ID: wpr-101985
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: We conducted a case-control study to evaluate the potential association between SERPINA1 genotypes (M1Val, M1Ala, S, and Z) and the risk COPD. METHODS: The study population consisted of 93 patients with COPD and 112 healthy controls. The polymerase chain reaction and restriction fragment length polymorphism for detecting the SERPINA1 variants. RESULTS: The M2 allele of the SERPINA1 gene was significantly associated with the risk of COPD in Koreans. The effect of the M2 allele on the risk of COPD was more pronounced in the subgroup <64 years. CONCLUSION: These results suggest that SERPINA1 polymorphisms may contribute to a genetic predisposition for COPD. However, additional studies with larger sample sizes are required to confirm our findings.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Polymorphism, Restriction Fragment Length
/
Case-Control Studies
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Polymerase Chain Reaction
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Sample Size
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Genetic Predisposition to Disease
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Pulmonary Disease, Chronic Obstructive
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Alleles
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Genotype
نوع الدراسة:
Etiology_studies
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Observational_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
En
مجلة:
Tuberculosis and Respiratory Diseases
السنة:
2008
نوع:
Article