Research progress of the endoplasmic reticulum-mitochondrial interactions in post-stroke cognitive impair-ment / 实用医学杂志
The Journal of Practical Medicine
; (24): 1023-1028, 2024.
Article
ي Zh
| WPRIM
| ID: wpr-1020868
المكتبة المسؤولة:
WPRO
ABSTRACT
Post-stroke cognitive impairment(PSCI),refers to a range of clinical syndromes of cognitive impairment caused by stroke.Although its specific pathogenesis is still unclear,many studies have confirmed that endoplasmic reticulum-mitochondria interaction has become a key hub for intracellular signal transduction and substance metabolism,and its regulation of various biological processes,such as Ca2+ balance,lipid metabolism,mitochondrial dynamics,autophagy,and neuroinflammation,is closely related to the development of PSCI.There-fore,in this paper,we will review the various functions of endoplasmic reticulum-mitochondrial interactions and explore their specific roles in PSCI,in order to discover new therapeutic targets and provide new theoretical basis and references for the development of PSCI-targeted drugs in the future.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
The Journal of Practical Medicine
السنة:
2024
نوع:
Article