Biological function and action mechanism of prefoldin 5 and its advancements in malignant tumors / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 237-240, 2024.
Article
ي Zh
| WPRIM
| ID: wpr-1030440
المكتبة المسؤولة:
WPRO
ABSTRACT
Prefoldin (PFDN), a hexameric chaperone complex, is crucial for the correct folding of nascent proteins. PFDN5, a subunit of PFDN, also known as MM-1, plays an essential role in regulating cell migration and senescence. Emerging evidences suggest that PFDN-5 deletion or mutation significantly contributes to the initiation and progression of multiple cancers and the prognosis of patients. In this paper, recent researches on the biological underpinnings of PFDN-5 and its anti-cancer prospect are reviewed, aiming to provide a novel potential therapeutic target for the treatment of malignancies.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Cancer Research and Clinic
السنة:
2024
نوع:
Article