Investigating the role of UBE2T in lung adenocarcinoma based on GEO database / 中国现代医生

ABSTRACT

@#Objective To investigate the role of ubiquitin binding enzyme EZT(UBE2T)in lung adenocarcinoma by integrating single-cell sequencing data with the TCGA database,in order to provide insights into the specific molecular mechanisms of UBE2T in lung adenocarcinoma.Methods Single-cell sequencing data was downloaded from the GEO database(GSE117570),and R language was used for quality control and analysis of the data.Additionally,online tools were employed to analyze lung adenocarcinoma-related data from the TCGA database.The potential target genes associated with UBE2T were identified by integrating TCGA and single-cell sequencing data.Results Differential analysis using the TCGA database successfully demonstrated that UBE2T could serve as an independent prognostic factor in lung adenocarcinoma,and it was correlated with poor patient outcomes.Integration of single-cell sequencing data revealed that UBE2T-associated genes were mainly distributed in mononuclear cells and T cells.Furthermore,analysis using the CancerSEA database suggested a close association between UBE2T and cell cycle regulation.Conclusion UBE2T may play a role in promoting the occurrence and development of lung adenocarcinoma through the regulation of the cell cycle.