Research progress of exosomal proteins in occurrence,development mechanism and diagnosis of lung cancer / 中国生物制品学杂志

ABSTRACT

@#At present,early screening and diagnosis of lung cancer are the key to the prevention and treatment of lung cancer. Pathological biopsy is the“gold standard”for the diagnosis of primary lung cancer. However,as an invasive diagnosis,it is not suitable for early screening and follow-up of lung cancer. Studies have shown that tumor-derived exosomes are enriched in tumor-related and specific proteins,which transmit information through various body fluids and play an important role in the occurrence and development of tumors. Therefore,these proteins on exosomes are expected to serve as new indicators for early screening and follow-up of lung cancer through noninvasive liquid biopsy. This paper reviewed the mechanism of exosomal proteins in the occurrence and development of lung cancer and the research progress and existing problems in the diagnosis of lung cancer.