The critical time of avian leukosis virus subgroup J-mediated immunosuppression during early stage infection in specific pathogen-free chickens
J. vet. sci
; J. vet. sci;: 235-241, 2011.
Article
ي En
| WPRIM
| ID: wpr-108028
المكتبة المسؤولة:
WPRO
ABSTRACT
The critical time of avian leukosis virus subgroup J (ALV-J)-mediated immunosuppression was determined by body weight, relative immune organ weight, histopathology, and presence of group specific antigen and antibodies in specific pathogen-free (SPF) chickens. CD4+ and CD8+ cell activity in the spleen, total and differential leukocyte counts in blood, and viral RNA levels in spleen were measured. Significant growth suppression was observed in the two ALV-J-infected groups. A strong immune response by infected groups was present in spleen at 2-weeks-of-age, but after 4-weeks-of-age, the response decreased quickly. The thymus and bursa showed persistent immunosuppression until 4-weeks-of-age. Proliferation of fibroblasts and dendritic cells were observed in immune organs at 4- and 5-weeks-of-age. However, the granulocyte cell number was markedly lower in the infected groups than in the control group. In group 1 (day 1 infection) CD4+ cells increased during the second week but significantly decreased during the fourth week, while group 2 (day 7 infection) showed the opposite effect. Viral RNA increased significantly by the fourth week. These data identify 3~4 weeks post-infection as the key time at which the ALV-J virus exerts its immunosuppressive effects on the host.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Poultry Diseases
/
Spleen
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Body Weight
/
RNA, Viral
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Avian Leukosis
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Enzyme-Linked Immunosorbent Assay
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CD4 Antigens
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Chickens
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China
/
CD8 Antigens
المحددات:
Animals
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
J. vet. sci
السنة:
2011
نوع:
Article