Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
Biomolecules & Therapeutics
; : 343-348, 2013.
Article
ي En
| WPRIM
| ID: wpr-108279
المكتبة المسؤولة:
WPRO
ABSTRACT
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Skin
/
United States Food and Drug Administration
/
Computer Simulation
/
Mass Screening
/
Monophenol Monooxygenase
/
Melanosomes
/
Epidermis
/
Hesperidin
/
Korea
/
Melanins
نوع الدراسة:
Prognostic_studies
/
Screening_studies
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Biomolecules & Therapeutics
السنة:
2013
نوع:
Article