Focused Update on Primary Stroke Prevention in Patients with Atrial Fibrillation in Korean Clinical Practice Guidelines for Stroke / 대한뇌졸중학회지
Korean Journal of Stroke
; : 106-115, 2012.
Article
ي Ko
| WPRIM
| ID: wpr-109665
المكتبة المسؤولة:
WPRO
ABSTRACT
Pivotal clinical trials testing the efficacy of new antithrombotics for the prevention of stroke and systemic embolism in patients with atrial fibrillation have been published since the release of the first edition of Korean clinical practice guidelines for primary stroke prevention. From July 2007 to August 2012, 5 clinical studies and update of guidelines in Europe and North America were identified through systematic search. In patients with atrial fibrillation who were unsuitable for warfarin, the combination of clopidogrel and aspirin reduced the risk of stroke at the cost of increased major bleedings as compared to aspirin. In patients with nonvalvular atrial fibrillation and risk factors for stroke, new oral anticoagulants, dabigatran, rivaroxaban and apixaban, were as effective as or more effective than warfarin in preventing stroke or systemic embolism. The risks of major bleeding with novel anticoagulants were similar to or lower than that of warfarin. Particularly, the risk of intracranial bleeding was significantly lower with novel anticoagulants than with warfarin. In this report, we summarized the new evidences and updated our recommendations for primary stroke prevention in patients with atrial fibrillation.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Primary Prevention
/
Pyrazoles
/
Pyridones
/
Atrial Fibrillation
/
Thiophenes
/
Warfarin
/
Benzimidazoles
/
Ticlopidine
/
Aspirin
/
Morpholines
نوع الدراسة:
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
البلد/الأقليم حسب الموضوع:
America do norte
/
Europa
اللغة:
Ko
مجلة:
Korean Journal of Stroke
السنة:
2012
نوع:
Article