Impact on Long-term Adverse Cardiac Events of Troponin T or Creatine Kinase-MB Release after Percutaneous Transluminal Coronary Angioplasty
Korean Circulation Journal
; : 949-957, 2002.
Article
ي Ko
| WPRIM
| ID: wpr-115500
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
The impact on long-term adverse cardiac events of troponin T (TnT) or creatine kinase-MB (CK-MB) release after percutaneous transluminal coronary angioplasty (PTCA) is not well defined. The purpose of the study is to evaluate the effect of elevated TnT or CK-MB on the late major adverse cardiac events [MACE ; Q wave myocardial infarction (MI), revascularization, or cardiac death]. SUBJECTS ANDMETHODS:
Study population were 207 consecutive patients (M F=148 59, mean 60.8+/-9.2 years) who underwent PTCA. Patients with acute MI, unstable angina with abnormal levels of TnT or CK-MB, or newly developed Q MI after PTCA were excluded. Cardiac enzyme levels were measured before and 8, 24 hours after PTCA for CK-MB, and before and 16 hours after PTCA for TnT. Group I (n=181, 87.4%) had normal levels of both after PTCA. Group II (n=26, 12.6%) had abnormal levels of CK-MB (>or=16 U/L) and/or TnT (>or=0.2 ng/mL). 1-year follow-up was available in 201 (97.1%) patients.RESULTS:
Incidence of non-Q MI after PTCA was 26/207 (12.6%). Major complications such as acute coronary occlusion, side branch occlusion, and major dissection were significantly associated with elevation of TnT or CK-MB after PTCA (p=0.01). However, elevation of CK-MB or TnT was not significantly associated with late MACE by Kaplan-Meier survival curve (p=0.46). During 1-year follow-up, event free rate of group I and II were 76.6% and 69.2%, respectively.CONCLUSION:
Acute coronary occlusion, side branch occlusion, or major dissection can increase the level of TnT or CK-MB after PTCA. But, elevation of CK-MB or TnT after PTCA dose not significantly influence on late MACE.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Troponin
/
Trinitrotoluene
/
Angioplasty, Balloon, Coronary
/
Incidence
/
Follow-Up Studies
/
Angioplasty
/
Troponin T
/
Creatine
/
Creatine Kinase
/
Coronary Occlusion
نوع الدراسة:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
المحددات:
Humans
اللغة:
Ko
مجلة:
Korean Circulation Journal
السنة:
2002
نوع:
Article