Combination Chemotherapy with 5-Fluorouracil and Heptaplatin as First-line Treatment in Patients with Advanced Gastric Cancer
Journal of Korean Medical Science
; : 369-373, 2004.
Article
ي En
| WPRIM
| ID: wpr-124478
المكتبة المسؤولة:
WPRO
ABSTRACT
Heptaplatin is a recently developed platinum derivative. This agent has been reported to have a response rate of 17% as a single agent, and tolerable toxicity in the treatment of advanced gastric cancer. The aim of this study was to evaluate the efficacy and toxicity of a combination of 5-fluorouracil (5-FU) and heptaplatin in patients with advanced gastric cancer. Forty-seven chemotherapy-naive patients with advanced or recurred gastric cancer were recruited. 5-FU was administered over 120 hr by continuous intravenous infusion from day 1 to 5, at a daily dose of 1,000 mg/m2 and heptaplatin was administered over 1 hr by intravenous infusion on day 1 at 400 mg/m2, and this cycle was repeated every 4 weeks. The response rate was 21%, median progression-free survival was 1.9 months (95% CI, 1.6 to 2.2 months). Median overall survival was 6.2 months (95% CI, 4 to 8.4 months) and the 1-yr survival rate was 29% for all patients. The most frequent toxicity was proteinuria. Toxicities were generally mild and reversible. This study demonstrates that the combination of 5-FU/heptaplatin combination is less active but tolerated in patients with advance gastric cancer.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Organoplatinum Compounds
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Stomach Neoplasms
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Time Factors
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Antineoplastic Combined Chemotherapy Protocols
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Follow-Up Studies
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Treatment Outcome
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Disease-Free Survival
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Fluorouracil
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Malonates
نوع الدراسة:
Observational_studies
/
Prognostic_studies
المحددات:
Adult
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Aged
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Female
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Humans
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Male
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2004
نوع:
Article