Combined Treatment of Photodynamic Therapy and Bevacizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Korean Journal of Ophthalmology
; : 231-237, 2011.
Article
ي En
| WPRIM
| ID: wpr-125054
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
To evaluate the outcome of a combined photodynamic therapy and intravitreal injection of bevacizumab in choroidal neovascularization secondary to age-related macular degeneration.METHODS:
Photodynamic therapy (PDT) was administered to 28 eyes followed by 3 consecutive bevacizumab injections. Patients were followed-up for more than 12 months. At baseline, 1, 3, 6, and 12 months post PDT, visual acuity (VA) and central macular thickness were measured using optical coherence tomography.RESULTS:
The mean VA was significantly improved from logarithm of the minimal angle of resolution 0.86 at baseline to 0.69 at 1 month (p = 0.011), 0.63 at 3 months (p = 0.003), 0.64 at 6 months (p = 0.004) and 0.60 at 12 months (p < 0.001). Central macular thickness decreased significantly from 328.3 microm at baseline to 230.0 microm at 6 months and 229.9 microm at 1 year (p < 0.001). Reinjection mean number was 0.4 for 6 months and 0.8 for 12 months. By 1 year, retreatment was performed in 10 eyes (36%).CONCLUSIONS:
PDT combined with three consecutive intraviteal bevacizumab injections was effective in improving VA and reducing central macular thickness.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Photochemotherapy
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Porphyrins
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Fluorescein Angiography
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Visual Acuity
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Retrospective Studies
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Follow-Up Studies
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Treatment Outcome
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Photosensitizing Agents
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Choroidal Neovascularization
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Angiogenesis Inhibitors
نوع الدراسة:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
المحددات:
Aged
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Female
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Humans
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Male
اللغة:
En
مجلة:
Korean Journal of Ophthalmology
السنة:
2011
نوع:
Article