Levels of Soluble Interleukin-2 Receptors in Serum of Patients with Behçet's Disease
Annals of Dermatology
; : 13-16, 1993.
Article
ي En
| WPRIM
| ID: wpr-143591
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: Interleukin-2 receptor (IL-2) is expressed and released predominantly activated T lymphocyte. Increased serum levels of soluble IL-2R have been noted in a variety of autoimmune diseases and in conditions associated with T lymphocyte activation. OBJECTIVE: We aimed to examine whether the T lymphocyte activation has any association with the pathogenesis of Behçet's disease. METHOD: We have measured the serum level of soluble IL-2R in serum samples obtained from 67 patients with Behçet's disease and 30 healthy people as a control group, using a double-antibody sandwich enzyme-linked immunosorbent assay technique. RESULTS: Serum soluble IL-2R levels were found to be significantly elevated in the group of Behçet's disease as compared with the control group. No significant differences were found within clinical subtypes of Behçet's disease. CONCLUSION: These findings suggest the presence of an ongoing T lymphocyte activation in this disease process.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Autoimmune Diseases
/
Enzyme-Linked Immunosorbent Assay
/
Lymphocyte Activation
/
Lymphocytes
/
Receptors, Interleukin-2
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Interleukin-2
/
Methods
المحددات:
Humans
اللغة:
En
مجلة:
Annals of Dermatology
السنة:
1993
نوع:
Article