The Insulin Resistance but Not the Insulin Secretion Parameters Have Changed in the Korean Population during the Last Decade
Diabetes & Metabolism Journal
; : 117-125, 2015.
Article
ي En
| WPRIM
| ID: wpr-147133
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
This study aimed to compare the patterns of insulin secretion and resistance between Korean subjects in the 1990s and 2000s.METHODS:
Insulin secretion and resistance indices were calculated from subjects who underwent 75-g oral glucose tolerance tests in the year 1997 to 1999 and 2007 to 2011 at the Seoul St. Mary's Hospital, Korea.RESULTS:
A total of 578 subjects from the 1990s (mean age, 48.5 years) and 504 subjects from the 2000s (mean age, 50.2 years) were enrolled. Compared with the subjects from the 1990s, those from the 2000s exhibited increased insulin resistance (increased homeostatic model assessment for insulin resistance), and reduced insulin sensitivity (reduced Matsuda index and quantitative insulin sensitivity check index), regardless of their glucose tolerance status. However, insulinogenic index did not reveal significant differences between the 2 decades in subjects with or without diabetes. A distinct relationship was confirmed between Matsuda index and total area under the curve (insulin/glucose) in each glucose tolerance group. The mean product of the Matsuda index and the total area under the curve (insulin/glucose) as well as the oral disposition index, was lower in subjects with normal glucose tolerance from the 2000s than in those from the 1990s.CONCLUSION:
After rapid economic growth and changes in lifestyle patterns, insulin resistance has worsened across the glucose tolerance status; however, the insulin secretory function remained unchanged, which resulted in an increase in the susceptibility to the development of type 2 diabetes mellitus among Korean subjects without diabetes. We could not rule out the potential selection bias and therefore, further studies in general Korean population are needed.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Insulin Resistance
/
Economic Development
/
Selection Bias
/
Diabetes Mellitus
/
Diabetes Mellitus, Type 2
/
Seoul
/
Glucose
/
Glucose Tolerance Test
/
Insulin
/
Korea
نوع الدراسة:
Prognostic_studies
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Diabetes & Metabolism Journal
السنة:
2015
نوع:
Article