Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
Biomolecules & Therapeutics
; : 249-258, 2017.
Article
ي En
| WPRIM
| ID: wpr-151382
المكتبة المسؤولة:
WPRO
ABSTRACT
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-ζ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-ζ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Protein Kinases
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Water
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Blotting, Western
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Dizocilpine Maleate
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N-Methylaspartate
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Cognition
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Cognition Disorders
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Syzygium
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Hippocampus
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Memory
المحددات:
Animals
اللغة:
En
مجلة:
Biomolecules & Therapeutics
السنة:
2017
نوع:
Article