Third-line docetaxel chemotherapy for recurrent and metastatic gastric cancer
The Korean Journal of Internal Medicine
; : 314-321, 2013.
Article
ي En
| WPRIM
| ID: wpr-155789
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND/AIMS:
To determine the efficacy and toxicity of docetaxel as a third-line therapy for patients with relapsed gastric cancer who have undergone modified oxaliplatin-fluorouracil (m-FOLFOX)-4 and modified irinotecan-fluorouracil (m-FOLFIRI) regimens.METHODS:
We analyzed 33 patients who had been histologically diagnosed with adenocarcinoma of the stomach and who had progressed after m-FOLFOX-4 and m-FOLFIRI regimens. Patients were treated with cycles of 75 mg/m2 docetaxel on day 1 every 3 weeks.RESULTS:
The median age of the patients was 56.0 years (range, 31.0 to 74.0), and 73% of the patients (24/33) had an Eastern Cooperative Oncology Group performance status of 0 or 1. All patients were evaluated in terms of tumor response five (15%), nine (27%), and 19 (58%) patients experienced a partial response, stable disease, and progressive disease, respectively. The median time to progression was 2.1 months (95% confidence interval [CI], 1.63 to 2.58), and overall survival was 4.7 months (95% CI, 3.20 to 6.20), from the start of the docetaxel regimen. Assessing patients' toxicity profiles, the median number of cycles was 2.0 (range, 1.0 to 12.0). The major hematologic toxicities included grade 3 to 4 neutropenia (19/33, 58%), grade 3 to 4 thrombocytopenia (2/33, 6%), and grade 3 to 4 anemia (5/33, 15%). Neutropenic fever developed in three patients (3/33, 9%). The nonhematological toxicities were nausea and vomiting (10/33, 30%), abdominal pain (4/33, 12%), skin rash (1/33, 3%), and fluid retention (3/33, 9%).CONCLUSIONS:
Docetaxel is a feasible third-line therapy regimen for patients with advanced gastric cancer after m-FOLFIRI and m-FOLFOX-4 regimens.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Stomach Neoplasms
/
Adenocarcinoma
/
Salvage Therapy
/
Antineoplastic Protocols
/
Taxoids
/
Republic of Korea
/
Neoplasm Recurrence, Local
/
Antineoplastic Agents
المحددات:
Adult
/
Aged
/
Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
The Korean Journal of Internal Medicine
السنة:
2013
نوع:
Article