RET Fusion Genes in Korean Non-Small Cell Lung Cancer
Journal of Korean Medical Science
; : 1555-1558, 2013.
Article
ي En
| WPRIM
| ID: wpr-155940
المكتبة المسؤولة:
WPRO
ABSTRACT
Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Oncogene Proteins, Fusion
/
Kinesins
/
Sequence Analysis, DNA
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Carcinoma, Non-Small-Cell Lung
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Cytoskeletal Proteins
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Asian People
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Proto-Oncogene Proteins c-ret
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Republic of Korea
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Lung Neoplasms
المحددات:
Female
/
Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2013
نوع:
Article