Two Cases of Acute Leukopenia Induced by Colchicine with Concurrent Immunosuppressants Use in Behcet's Disease
Yonsei Medical Journal
; : 171-173, 2008.
Article
ي En
| WPRIM
| ID: wpr-158183
المكتبة المسؤولة:
WPRO
ABSTRACT
Colchicine-induced leukopenia usually occurrs in intentional or accidental overdoses or inappropriate use in combination with intravenous and oral colchine; however, there have been several reports of hematologic toxicity in short-term and small-dose colchicine medication courses. We present two cases of leukopenia induced by colchicine use concurrent with immunosuppressants in Behcet's disease. We postulate that the mechanism of colchicine-induced leukopenia might be the destruction of circulating leukocytes and an inhibition of leukocyte production by the immediate and direct toxic effect of colchicine on idiosyncrasies unique to each patient. The concurrently administered immunosuppressant might decrease the threshold for hematologic toxicity of colchicine in the leukocytes and their precursor cells.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Time Factors
/
Blood Cell Count
/
Colchicine
/
Behcet Syndrome
/
Treatment Failure
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Immunosuppressive Agents
/
Leukopenia
المحددات:
Aged
/
Female
/
Humans
اللغة:
En
مجلة:
Yonsei Medical Journal
السنة:
2008
نوع:
Article