Comparison of Effects of Alendronate and Raloxifene on Lumbar Bone Mineral Density, Bone Turnover, and Lipid Metabolism in Elderly Women with Osteoporosis
Yonsei Medical Journal
; : 119-128, 2008.
Article
ي En
| WPRIM
| ID: wpr-158192
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
To compare the effects of alendronate and raloxifene on lumbar bone mineral density (BMD), bone turnover, and lipid metabolism in elderly women with osteoporosis. Subjects andMethods:
One hundred twenty-two postmenopausal women with osteoporosis (mean age 69.4 years) were randomly divided into 2 groups of 61 patients the alendronate group and the raloxifene group. BMD of the lumbar spine, urinary level of cross-linked N-terminal telopeptides of type I collagen (NTX), and serum levels of alkaline phosphatase (ALP), total cholesterol (TC), high and low density lipoprotein cholesterols (LDL-C and HDL-C, respectively), and triglycerides (TG) were measured during the 12-month-treatment period.RESULTS:
The trial in 50 patients in the alendronate group and 52 patients in the raloxifene group could be completed. Both alendronate and raloxifene increased lumbar BMD (+8.0% and +2.4% at 12 months, respectively), followed by reductions of urinary NTX level and serum ALP level; however, the effects of alendronate were more pronounced than those of raloxifene. Only raloxifene reduced the serum levels of TC and LDL-C (-3.9% and -7.7% at 12 months, respectively), without any significant effect on the serum HDL-C and TG levels.CONCLUSION:
The present study confirmed the efficacy of alendronate greater than raloxifene in increasing lumbar BMD through its effect on marked reduction of the bone turnover more than by raloxifene, and some beneficial effects of raloxifene on lipid metabolism in elderly women with osteoporosis.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Osteoporosis
/
Phosphorus
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Spine
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Biomarkers
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Bone Density
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Calcium
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Alendronate
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Raloxifene Hydrochloride
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Fractures, Bone
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Lipid Metabolism
المحددات:
Aged
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Female
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Humans
اللغة:
En
مجلة:
Yonsei Medical Journal
السنة:
2008
نوع:
Article