A case of allopurinol-induced granulomatous hepatitis with ductopenia and cholestasis / 대한간학회지
The Korean Journal of Hepatology
; : 97-101, 2008.
Article
ي Ko
| WPRIM
| ID: wpr-160185
المكتبة المسؤولة:
WPRO
ABSTRACT
Allopurinol-induced hypersensitivity syndrome is characterized by an idiosyncratic reaction involving multiple-organs, which usually begins 2 to 6 weeks after starting allopurinol. In rare cases, the adverse reactions to allopurinol are accompanied by a variety of liver injury, such as reactive hepatitis, granulomatous hepatitis, vanishing bile duct syndrome, or fulminant hepatic failure. Here we report a case with granulomatous hepatitis and ductopenia. A 69-year-old man with chronic renal failure, hyperuricemia, and previously normal liver function presented with jaundice, skin rash, and fever 2 weeks after taking allopurinol (200 mg/day). In histopathology, a liver biopsy specimen showed mild spotty necrosis of hepatocytes, marked cholestasis in parenchyma, and some granulomas in the portal area. There were vacuolar degeneration in the interlobular bile ducts and ductopenia in the portal tracts. Pathologic criteria strongly suggested the presence of allopurinol-induced granulomatous hepatitis with ductopenia and cholestasis. The patient fully recovered following the early administration of systemic corticosteroid therapy.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Bile Duct Diseases
/
Bile Ducts, Intrahepatic
/
Allopurinol
/
Cholestasis
/
Drug Eruptions
/
Chemical and Drug Induced Liver Injury
/
Granuloma
/
Kidney Failure, Chronic
/
Antimetabolites
المحددات:
Aged
/
Humans
/
Male
اللغة:
Ko
مجلة:
The Korean Journal of Hepatology
السنة:
2008
نوع:
Article