Interleukin-32 Gamma as a New Face in Inflammatory Bone Diseases
Journal of Rheumatic Diseases
; : 14-20, 2017.
Article
ي En
| WPRIM
| ID: wpr-160555
المكتبة المسؤولة:
WPRO
ABSTRACT
Interleukin-32 (IL-32), a recently identified pro-inflammatory cytokine, is involved in the pathogenesis and progression of infections, cancer, chronic inflammation, and autoimmune disease. IL-32γ is the most active isoform in cell death and cell activation among nine distinct isoforms of IL-32. IL-32γ potentiates both osteogenic and osteoclastogenic capacities, and is critical in the coupling of bone resorption and bone formation for maintenance of bone homeostasis. IL-32γ is strongly associated with inflammatory bone disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. In this review, we summarize current research on the role of IL-32γ in inflammatory bone disorders, highlighting this cytokine as a novel target for prognostic marker and control of these diseases.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Osteogenesis
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Osteoporosis
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Arthritis, Rheumatoid
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Autoimmune Diseases
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Spondylitis, Ankylosing
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Bone Diseases
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Bone Resorption
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Cell Death
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Protein Isoforms
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Homeostasis
اللغة:
En
مجلة:
Journal of Rheumatic Diseases
السنة:
2017
نوع:
Article