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Interleukin-32 Gamma as a New Face in Inflammatory Bone Diseases
Article ي En | WPRIM | ID: wpr-160555
المكتبة المسؤولة: WPRO
ABSTRACT
Interleukin-32 (IL-32), a recently identified pro-inflammatory cytokine, is involved in the pathogenesis and progression of infections, cancer, chronic inflammation, and autoimmune disease. IL-32γ is the most active isoform in cell death and cell activation among nine distinct isoforms of IL-32. IL-32γ potentiates both osteogenic and osteoclastogenic capacities, and is critical in the coupling of bone resorption and bone formation for maintenance of bone homeostasis. IL-32γ is strongly associated with inflammatory bone disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. In this review, we summarize current research on the role of IL-32γ in inflammatory bone disorders, highlighting this cytokine as a novel target for prognostic marker and control of these diseases.
الموضوعات
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النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Osteogenesis / Osteoporosis / Arthritis, Rheumatoid / Autoimmune Diseases / Spondylitis, Ankylosing / Bone Diseases / Bone Resorption / Cell Death / Protein Isoforms / Homeostasis اللغة: En مجلة: Journal of Rheumatic Diseases السنة: 2017 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Osteogenesis / Osteoporosis / Arthritis, Rheumatoid / Autoimmune Diseases / Spondylitis, Ankylosing / Bone Diseases / Bone Resorption / Cell Death / Protein Isoforms / Homeostasis اللغة: En مجلة: Journal of Rheumatic Diseases السنة: 2017 نوع: Article