The feasibility and efficacy of gonadotropin-releasing hormone agonists for prevention of chemotherapy induced ovarian failure in patient with gynecological malignancies
Obstetrics & Gynecology Science
; : 478-483, 2014.
Article
ي En
| WPRIM
| ID: wpr-17033
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE: To assess the effects of a gonadotropin-releasing hormone agonist (GnRH-a) depot (Leuprolide acetate) in women with gynecologic cancer receiving chemotherapy while taking a continuous add-back on the prevention of premature ovarian failure. METHODS: Fourteen premenopausal patients with gynecological malignancies who had undergone conservation of ovaries surgery received a GnRH-a depot plus add-back until chemotherapy was completed. Four weeks thereafter, a hormonal profile (follicle stimulating hormone) was measured. RESULTS: The mean follicle stimulating hormone level was 15.8 IU/L. All patients exhibited a restoration of ovarian failure during follow-up. One patient became pregnant during the follow-up period. CONCLUSION: In the short term, GnRH-a appears to protect ovarian function and ability to achieve pregnancy following chemotherapy. The result of our study needs further elucidation in a large randomized controlled trial.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Ovarian Neoplasms
/
Ovary
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Uterine Cervical Neoplasms
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Follow-Up Studies
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Gonadotropin-Releasing Hormone
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Chemotherapy, Adjuvant
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Primary Ovarian Insufficiency
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Drug Therapy
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Fertility Preservation
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Follicle Stimulating Hormone
نوع الدراسة:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
المحددات:
Female
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Humans
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Pregnancy
اللغة:
En
مجلة:
Obstetrics & Gynecology Science
السنة:
2014
نوع:
Article