Imatinib Plasma Monitoring-Guided Dose Modification for Managing Imatinib-Related Toxicities in Gastrointestinal Stromal Tumor Patients
Journal of Korean Medical Science
; : 1248-1252, 2013.
Article
ي En
| WPRIM
| ID: wpr-173127
المكتبة المسؤولة:
WPRO
ABSTRACT
Imatinib, the first-line treatment in patients with advanced gastrointestinal stromal tumors (GIST), is generally well tolerated, although some patients have difficulty tolerating the standard dose of 400 mg/day. Adjusting imatinib dosage by plasma level monitoring may facilitate management of patients who experience intolerable toxicities due to overexposure to the drug. We present two cases of advanced GIST patients in whom we managed imatinib-related toxicities through dose modifications guided by imatinib plasma level monitoring. Imatinib blood level testing may be a promising approach for fine-tuning imatinib dosage for better tolerability and optimal clinical outcomes in patients with advanced GIST.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Piperazines
/
Pyrimidines
/
Benzamides
/
Tomography, X-Ray Computed
/
Exons
/
Drug Monitoring
/
Proto-Oncogene Proteins c-kit
/
Gastrointestinal Stromal Tumors
/
Positron-Emission Tomography
/
Gastrointestinal Neoplasms
المحددات:
Aged
/
Humans
/
Male
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2013
نوع:
Article