Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to Helicobacter pylori Infection Status: A Single-Center Experience
Gut and Liver
; : 408-414, 2014.
Article
ي En
| WPRIM
| ID: wpr-175280
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treatment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas.METHODS:
In total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treatment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas.RESULTS:
Of the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treatment, and complete remission was achieved in 31 of the 39 patients (80%) with H. pylori-positive MALT lymphoma and in five (56%) of the nine patients with H. pylori-negative MALT lymphoma; no significant difference was observed between the groups (p=0.135). The other treatment modalities, including radiation therapy, chemotherapy, and surgery, were effective irrespective of H. pylori infection status, with no significant difference in the treatment response between H. pylori-positive and H. pylori-negative MALT lymphomas.CONCLUSIONS:
H. pylori eradication therapy may be considered as a first-line treatment regardless of H. pylori infection status.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Stomach Neoplasms
/
Retrospective Studies
/
Helicobacter pylori
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Helicobacter Infections
/
Gastroscopy
/
Treatment Outcome
/
Lymphoma, B-Cell, Marginal Zone
/
Gastric Mucosa
/
Antineoplastic Agents
نوع الدراسة:
Observational_studies
/
Risk_factors_studies
المحددات:
Adult
/
Aged
/
Female
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Humans
/
Male
اللغة:
En
مجلة:
Gut and Liver
السنة:
2014
نوع:
Article