Expression of Genetic Polymorphism of Interleukin-10 (IL-10) and Tumor Necrosis Factor-beta (TNF-beta) in Patients with Atopic Dermatitis / 대한피부과학회지
Korean Journal of Dermatology
; : 488-495, 2002.
Article
ي Ko
| WPRIM
| ID: wpr-177378
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
Atopic dermatitis (AD) is a common inflammatory skin disease. Atopic dermatitis is associated with increased IL-4, IL-5, IL-10 and IL-13 but decreased INF-gamma and TNF production. IL-10 production has been implicated in autoimmunity because of its effect on B-cell proliferation and antibody production. The study of IL-10 gene polymorphism is of interest because of the pivotal role of IL-10 in the regulation of inflammatory and immune responses. TNF-beta significantly upregulates INF-gamma but downregulates IL-5, IL-13 and IgE, which suggests a potential role of TNF-beta in the pathogenesis of atopic dermatitis.OBJECTIVES:
We have investigated polymorphism of IL-10 promoter gene and TNF-beta gene.METHODS:
Seventy one patients with atopic dermatitis and one hundred and sixty six normal subjects participated in this study with analysis of polymorphism of IL-10 promoter (-1082), (-819) gene and seventy one patients with atopic dermatitis and one hundred and forty one normal subjects participated in the analysis of polymorphism of TNF-beta gene. The patients in this study were recently diagnosed with atopic dermatitis.RESULTS:
The frequency of IL-10 promoter (-1082) genotypes (A/A, A/G, G/G), genes (A, G), IL-10 promoter (-819) genotypes (T/T, T/C, C/C) and genes (T, C) did not show any significant difference between atopic dermatitis patients and normal controls. There was no significant difference in the frequency of TNFB genotypes (TNFB*1/TNFB*1, TNFB*1/TNFB*2, TNFB*2/TNFB*2) and genes (TNFB*1, TNFB*2) in patients of atopic dermatitis and normal controls.CONCLUSION:
The results of this study suggest that the other regions of the IL-10 promoter gene and TNFB gene should be investigated for polymorphism of atopic dermatitis. And the difference of IL-10 promoter and TNFB gene polymorphism between caucasian and Korean needs to be evaluated.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Polymorphism, Genetic
/
Skin Diseases
/
Immunoglobulin E
/
B-Lymphocytes
/
Autoimmunity
/
Interleukin-4
/
Interleukin-5
/
Lymphotoxin-alpha
/
Interleukin-10
/
Interleukin-13
المحددات:
Humans
اللغة:
Ko
مجلة:
Korean Journal of Dermatology
السنة:
2002
نوع:
Article