Expressions of E2F4 and E2F2 Transcription Factors in Breast Carcinoma
Korean Journal of Pathology
; : 301-306, 2005.
Article
ي Ko
| WPRIM
| ID: wpr-181742
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
The E2F family (E2F1 to E2F6) of transcription factors plays a key role in cell cycle progression. Some act as oncogenes and others act as tumor suppressor genes (TSG) in a tissue-specific manner. E2F4 may function as a TSG. However, the role of E2F4 in breast carcinogenesis remains controversial. Also the clinical impact of E2F2 expression on breast cancer remains unknown.METHODS:
Expressions of E2F4 and E2F2 were assessed immunohistochemically in 113 breast carcinomas and were compared with clinicopathological variables, expressions of G1/S checkpoint proteins (p16, cyclin D1 and Rb), and DNA ploidy to identify their possible role and to assess their prognostic value in breast cancer.RESULTS:
Expressions of E2F4 and E2F2 were detected in 48 cases (42.5%) and 66 cases (58.4%), respectively. Expressions of E2F4 and E2F2 were significantly correlated with large tumor size (p<0.001) and lymph node metastasis (p<0.001). There was no correlation between expressions of E2F4 or E2F2 and any other variables, including age, histologic grade, DNA ploidy and expressions of p16, cyclin D1 and Rb.CONCLUSIONS:
These results suggest that expressions of E2F4 and E2F2 are associated with growth and spread of breast cancer and indicate poor prognosis.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Oncogenes
/
Ploidies
/
Prognosis
/
Transcription Factors
/
Breast
/
Breast Neoplasms
/
DNA
/
Immunohistochemistry
/
Cell Cycle
/
Genes, Tumor Suppressor
نوع الدراسة:
Prognostic_studies
المحددات:
Humans
اللغة:
Ko
مجلة:
Korean Journal of Pathology
السنة:
2005
نوع:
Article